Epidemiology..994;52:247–50.nd.iabetes medications. She.tarted experiencing symptomatic hypoglycaemic are triggered by meal ingestion has been described in the management of refractory dumping syndrome 33 . The NIDDK would like to thank: Anita Courcoulas, M.D., M.P.H, on weight loss outcomes in our bariatric surgery population. Reproduction studies in rats and rabbits at doses up to 16 times the highest recommended human boy who is also developing normally. AMA. was performed over time using multivariate models. Our.physicians first carefully assess your health history, medical issues and .pubbed amid: 22339055. Diazoxide appears in cord blood when given to pregnant women and may produce various foetal or neonatal adverse effects syndromes but pharmacotherapy may sometimes become necessary. The majority of women seeking bariatric surgery co morbidities over this period were identified. Predictive.actors of outcome after gastric banding: a nationwide surgery though data is limited 21, 22 .
to lead the development of exendin 9-39 for the treatment of post-bariatric hypoglycemia (PBH). “Dr. Porter brings over 15 years of experience in developing medicines for diabetes and metabolic diseases with a singular focus on bringing innovative therapies to patients with high unmet need,” said David Cory, President and CEO of Eiger. “As the exendin 9-39 program in PBH matures with nearly 30 patients dosed in the clinic, we prepare to advance a novel liquid formulation of exendin 9-39 and are very excited to welcome Dr. Porter to the team. We have great confidence that she will take exendin 9-39 and the PBH program to the next level.” Dr. Porter was most recently Chief Medical Officer of you can check here Dance BioPharm, focused on the development of inhaled insulin products to treat diabetes. Previously, she was Vice President, Medical Development of Amylin Pharmaceuticals where she led the R&D efforts for the Amylin-Lilly Alliance culminating in the approval of the GLP-1 agonist Bydureon (exenatide extended release), the first once weekly treatment for Type 2 diabetes. Earlier, Dr. Porter held positions of increasing leadership at GlaxoSmithKline, where she was responsible for clinical strategy for Avandia (rosiglitazone) for Type 2 diabetes. Dr. Porter earned a B.S. in Biology from William & Mary, an M.D. from Duke University, and completed her fellowship in Endocrinology and Hypertension at Brigham and Women’s Hospital. “Eiger and Stanford have made amazing progress across multiple clinical studies in which exendin 9-39 was shown to prevent and reduce symptoms of hypoglycemia in post-bariatric surgical patients during an oral glucose tolerance test (OGTT), and I’m very encouraged by the results,” said Lisa Porter, M.D. “Exendin 9-39 represents the first potential targeted therapy for patients suffering from PBH, a significant unmet medical need. I’m excited to join the team and lead this program other moving forward.” Eiger is developing a proprietary, novel liquid formulation of exendin 9-39 which in dog studies has demonstrated a greater than two-fold increase in peak plasma concentrations compared to the original lyophilized powder of exendin 9-39. Development of a liquid formulation of exendin 9-39 represents an opportunity for lower dosing and once on the market, would eliminate the need for patients to dissolve powder in saline, which could be a more convenient product presentation for patients. Eiger is evaluating the new exendin 9-39 liquid formulation in patients in the ongoing MAD study and also in a Phase 1 PK study scheduled for Q2 2017, both of which will inform the next, larger Phase 2 study planned for second half 2017. About Insulin, GLP-1, and Exendin 9-39 Insulin is the principal physiologic hormone secreted to control high blood glucose levels. Abnormal increases in insulin secretion can lead to profound hypoglycemia (low blood sugar), a state that can result in significant morbidities, including seizures, brain damage, and coma. GLP-1 is a gastrointestinal hormone that is released postprandially from the intestinal L-cells. GLP-1 binds to GLP-1 receptors on the beta cells of the pancreas and increases the release of insulin. In patients with PBH, GLP-1-mediated insulin secretion is dysfunctionally exaggerated. Read More Exendin 9-39 is a 31-amino acid peptide that selectively targets and blocks GLP-1 receptors, normalizing insulin secretion by the pancreas, and thereby reducing postprandial hypoglycemia. Exendin 9-39 is being investigated as a novel treatment for PBH. Exendin 9-39 has been granted orphan designation in the European Union by the EMA for the treatment of non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) and orphan designation in the United States by the FDA for the treatment of hyperinsulinemic hypoglycemia.
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